Lens fiber cell morphogenesis

Across TCGA cell cohorts, RNA activity of the Lens fiber cell morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC88C, FAM227A, and EGFL8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC88C grouped by Lens fiber cell morphogenesis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CCDC88C →	+1.000	+1.248	.001	.004	3	5
BONE	FAM227A →	-0.899	-1.269	.004	.002	3	4
BONE	EGFL8 →	-0.944	-1.533	.003	<.001	3	4
URINARY_TRACT	BTBD9 →	-0.720	-1.281	.003	.003	3	4
OESOPHAGUS	NPIPA3 →	-0.897	-1.253	<.001	<.001	3	4
CNS	PMEPA1 →	-2.417	-1.013	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC88C by Lens fiber cell morphogenesis activity — STOMACH

Explore this box plot interactively →