Lens fiber cell morphogenesis

Across TCGA cell cohorts, RNA activity of the Lens fiber cell morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R12A, ACVR1B, and KCNJ12, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R12A grouped by Lens fiber cell morphogenesis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PPP1R12A →	+0.317	+0.137	.001	.009	2	7
SKIN	ACVR1B →	-0.131	-0.116	.002	.003	3	5
STOMACH	KCNJ12 →	-0.258	-0.178	<.001	<.001	3	5
LUNG_NSCLC_LUAD	KCNJ18 →	+0.186	+0.096	<.001	.003	3	5
LUNG_NSCLC_LUAD	FGF4 →	-0.117	-0.164	<.001	<.001	3	5
BREAST	KDM1A →	-0.368	-0.155	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R12A by Lens fiber cell morphogenesis activity — SKIN

Explore this box plot interactively →