Lens fiber cell morphogenesis

Across TCGA cell cohorts, RNA activity of the Lens fiber cell morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPHA2, INPP5B, and SPATA20, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lens fiber cell morphogenesis activity versus EPHA2 in CNS (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	EPHA2 →	+1.862	+0.389	<.001	<.001	3	5
CNS	INPP5B →	-0.973	-0.340	.003	<.001	3	4
LUNG_NSCLC_LUAD	SPATA20 →	-1.022	-0.208	.002	.004	3	4
STOMACH	NFIC →	-2.264	-0.336	.004	.006	3	4
OVARY	SGSM3 →	-1.074	-0.218	<.001	.004	3	4
LIVER	KMT2D →	-0.835	-0.271	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070309 vs EPHA2 — CNS

Explore this scatter interactively →