Lens fiber cell development

Across TCGA patient cohorts, RNA activity of the Lens fiber cell development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HLA-DPB1, PSTPIP1, and CD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lens fiber cell development activity versus HLA-DPB1 in LSCC (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HLA-DPB1 →	-0.483	-0.063	<.001	<.001	3	7
HNSC	PSTPIP1 →	-0.417	-0.083	<.001	<.001	3	7
BRCA	CD2 →	-0.795	-0.051	<.001	<.001	3	6
BRCA	CD38 →	-0.896	-0.043	<.001	.002	3	6
CCRCC	DEF6_S590 →	-0.541	-0.062	.001	.002	2	7
LSCC	IKZF1_S445 →	-1.086	-0.097	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070307 vs HLA-DPB1 — LSCC

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