Lens fiber cell development

Across TCGA cell cohorts, RNA activity of the Lens fiber cell development pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STXBP1, GPBP1L1, and STX1A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STXBP1 grouped by Lens fiber cell development-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	STXBP1 →	-1.855	-0.420	.002	.006	3	3
SKIN	GPBP1L1 →	+0.326	+0.555	<.001	.005	3	3
BLOOD_Leukemia	STX1A →	-1.307	-0.527	.008	.007	3	3
BLOOD_Leukemia	EXTL2 →	+1.001	+0.778	.003	.004	3	3
BLOOD_Leukemia	GRAMD2A →	+0.134	+0.537	.003	.006	3	3
BLOOD_Lymphoma	PDLIM1 →	-4.240	-1.688	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STXBP1 by Lens fiber cell development activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →