Lens fiber cell development

Across TCGA cell cohorts, RNA activity of the Lens fiber cell development pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIPI, SNW1, and LRFN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LIPI grouped by Lens fiber cell development-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LIPI →	+0.216	+0.169	.001	.002	2	5
LUNG_NSCLC_LUSC	SNW1 →	-0.345	-0.181	.004	.004	3	4
LUNG_NSCLC_LUSC	LRFN1 →	-0.256	-0.278	.009	.005	3	4
SOFT_TISSUE	UBTF →	+0.271	+0.325	.006	.002	3	4
SOFT_TISSUE	WNK3 →	-0.439	-0.400	.001	<.001	2	5
BREAST	NDC80 →	-0.357	-0.163	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LIPI by Lens fiber cell development activity — LARGE_INTESTINE

Explore this box plot interactively →