Lens fiber cell development

Across TCGA cell cohorts, RNA activity of the Lens fiber cell development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF24, ARHGAP29, and SLC25A6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lens fiber cell development activity versus ZNF24 in LUNG_NSCLC_LUAD (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZNF24 →	-0.634	-0.323	.004	.004	3	5
OVARY	ARHGAP29 →	+2.421	+0.296	.002	.003	3	4
OESOPHAGUS	SLC25A6 →	-1.822	-0.324	<.001	.002	3	4
LARGE_INTESTINE	FLRT1 →	-0.324	-0.227	.007	.002	3	4
PANCREAS	JADE3 →	-1.136	-0.438	.002	.004	3	4
BLOOD_Myeloma	PKLR →	-0.120	-0.402	.006	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070307 vs ZNF24 — LUNG_NSCLC_LUAD

Explore this scatter interactively →