Response to cGMP

Across TCGA patient cohorts, RNA activity of the Response to cGMP pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDH13, CACNA2D1, and GNL2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cGMP activity versus CDH13 in CCRCC (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CDH13 →	+0.595	+0.082	<.001	<.001	3	8
OV	CACNA2D1 →	+0.769	+0.076	<.001	<.001	3	8
BRCA	GNL2 →	-0.409	-0.066	<.001	<.001	3	8
CCRCC	ADARB1 →	+0.314	+0.081	<.001	<.001	3	8
CCRCC	RECK →	+0.475	+0.106	<.001	<.001	3	7
HNSC	SGCD →	+0.915	+0.099	<.001	<.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070305 vs CDH13 — CCRCC

Explore this scatter interactively →