Response to cGMP

Across TCGA patient cohorts, RNA activity of the Response to cGMP pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEF2C, AURKA, and ABCA8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cGMP activity versus MEF2C in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MEF2C →	+0.647	+0.238	<.001	<.001	3	6
UCEC	AURKA →	-0.976	-0.296	<.001	<.001	3	5
UCEC	ABCA8 →	+0.807	+0.170	.001	.009	3	5
UCEC	KIF2C →	-0.869	-0.279	<.001	<.001	3	5
UCEC	UBE2C →	-1.150	-0.289	<.001	<.001	3	5
UCEC	AURKB →	-0.846	-0.227	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070305 vs MEF2C — LSCC

Explore this scatter interactively →