Positive regulation of stress-activated protein kinase signaling cascade

Across TCGA patient cohorts, RNA activity of the Positive regulation of stress-activated protein kinase signaling cascade pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZAP70, CSE1L, and OLFML1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of stress-activated protein kinase signaling cascade activity versus ZAP70 in OV (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZAP70 →	+0.513	+0.033	.001	.001	3	8
LSCC	CSE1L →	-0.463	-0.061	<.001	<.001	3	8
BRCA	OLFML1 →	+0.911	+0.033	<.001	<.001	3	8
OV	RFC1_T506 →	-0.930	-0.030	.002	.007	3	8
OV	HSPA9 →	-0.419	-0.028	.005	.005	3	8
GBM	RCSD1 →	+0.529	+0.039	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070304 vs ZAP70 — OV

Explore this scatter interactively →