Positive regulation of stress-activated protein kinase signaling cascade

Across TCGA patient cohorts, RNA activity of the Positive regulation of stress-activated protein kinase signaling cascade pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAPP1, CHD6, and CASP5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of stress-activated protein kinase signaling cascade activity versus DAPP1 in BRCA (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DAPP1 →	+0.798	+0.673	.003	.009	2	6
COAD	CHD6 →	-0.596	-0.169	.002	.009	3	4
COAD	CASP5 →	+0.741	+0.145	.001	.004	3	4
COAD	ASXL1 →	-0.547	-0.175	<.001	.005	3	4
COAD	ANXA2P2 →	+0.692	+0.191	.005	.001	3	4
HNSC	PDS5B →	-0.474	-0.822	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070304 vs DAPP1 — BRCA

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