Positive regulation of stress-activated protein kinase signaling cascade

Across TCGA cell cohorts, RNA activity of the Positive regulation of stress-activated protein kinase signaling cascade pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCARB2, POLR2H, and EIF2AK4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of stress-activated protein kinase signaling cascade activity versus SCARB2 in SOFT_TISSUE (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SCARB2 →	+0.684	+0.360	.009	.002	3	4
BLOOD_Myeloma	POLR2H →	+0.820	+0.266	.004	.009	3	4
BLOOD_Lymphoma	EIF2AK4 →	+1.468	+0.238	.007	.008	3	4
BLOOD_Lymphoma	SLC25A43 →	+1.323	+0.243	.003	.001	3	3
BLOOD_Lymphoma	CPOX →	+1.337	+0.214	.004	.001	3	3
BLOOD_Leukemia	MTAP →	+1.527	+0.149	.007	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070304 vs SCARB2 — SOFT_TISSUE

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