Regulation of stress-activated protein kinase signaling cascade

Across TCGA patient cohorts, RNA activity of the Regulation of stress-activated protein kinase signaling cascade pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADH1B, TNS2, and NOC2L, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of stress-activated protein kinase signaling cascade activity versus ADH1B in BRCA (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ADH1B →	+1.067	+0.021	<.001	.001	3	8
CCRCC	TNS2 →	+0.282	+0.035	.009	<.001	3	8
LSCC	NOC2L →	-0.256	-0.027	<.001	<.001	3	8
OV	SGCD →	+0.529	+0.028	.008	<.001	3	7
LUAD	YME1L1 →	-0.386	-0.037	<.001	<.001	3	7
BRCA	CACNA2D1 →	+0.537	+0.027	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070302 vs ADH1B — BRCA

Explore this scatter interactively →