Regulation of stress-activated protein kinase signaling cascade

Across TCGA patient cohorts, RNA activity of the Regulation of stress-activated protein kinase signaling cascade pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMC2, IL1R2, and ITGB1BP1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of stress-activated protein kinase signaling cascade activity versus CMC2 in BRCA (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CMC2 →	+0.517	+0.997	.003	.009	3	2
COAD	IL1R2 →	+1.248	+0.619	.002	.006	3	2
BRCA	ITGB1BP1 →	+0.615	+0.954	<.001	.001	3	2
BRCA	S1PR4 →	+0.959	+0.942	.007	.001	3	2
BRCA	RGS10 →	+0.851	+0.879	<.001	.003	3	2
BRCA	FOXN2 →	+0.610	+1.181	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070302 vs CMC2 — BRCA

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