Regulation of stress-activated protein kinase signaling cascade

Across TCGA cell cohorts, RNA activity of the Regulation of stress-activated protein kinase signaling cascade pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDHB, AJUBA, and GRB7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SDHB grouped by Regulation of stress-activated protein kinase signaling cascade-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SDHB →	-0.477	-0.087	<.001	<.001	3	4
LUNG_NSCLC_LUAD	AJUBA →	-0.172	-0.077	.005	.008	3	4
BREAST	GRB7 →	-0.249	-0.107	<.001	<.001	3	4
BREAST	ATP6V0D2 →	-0.084	-0.090	.006	<.001	3	4
LIVER	ZNF367 →	+0.268	+0.104	.005	.007	3	4
LIVER	ATP6V1A →	+0.336	+0.085	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SDHB by Regulation of stress-activated protein kinase signaling cascade activity — BREAST

Explore this box plot interactively →