Cellular response to hydrogen peroxide

Across TCGA cell cohorts, RNA activity of the Cellular response to hydrogen peroxide pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MR1, EML2, and ACSL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MR1 grouped by Cellular response to hydrogen peroxide-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MR1 →	+1.170	+0.197	<.001	.001	3	5
BLOOD_Leukemia	EML2 →	+1.001	+0.167	.008	.002	3	5
BLOOD_Lymphoma	ACSL3 →	+1.372	+0.321	.001	<.001	3	4
LIVER	SIRPB1 →	-1.355	-0.255	.006	.001	3	4
CNS	C20orf27 →	-1.089	-0.238	<.001	.002	3	4
CNS	CREG1 →	+1.021	+0.165	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MR1 by Cellular response to hydrogen peroxide activity — OVARY

Explore this box plot interactively →