Cellular response to hydrogen peroxide

Across TCGA cell cohorts, RNA activity of the Cellular response to hydrogen peroxide pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA7A, SFI1, and ZNF225, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to hydrogen peroxide activity versus SEMA7A in BLOOD_Leukemia (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SEMA7A →	-1.469	-0.137	.002	<.001	3	5
CNS	SFI1 →	+0.714	+0.148	<.001	.001	3	5
CNS	ZNF225 →	+0.660	+0.165	<.001	<.001	3	5
KIDNEY	LINS1 →	+0.871	+0.236	.002	.008	3	4
STOMACH	POLK →	-1.071	-0.166	<.001	.001	3	4
STOMACH	RAP1GDS1 →	-0.929	-0.123	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070301 vs SEMA7A — BLOOD_Leukemia

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