Renal water absorption

Across TCGA cell cohorts, RNA activity of the Renal water absorption pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KANSL3, CCNA1, and GPR176, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KANSL3 grouped by Renal water absorption-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KANSL3 →	+0.661	+1.282	<.001	.001	3	4
LUNG_SCLC	CCNA1 →	+3.505	+1.466	.004	.004	3	4
LUNG_SCLC	GPR176 →	-2.123	-1.363	<.001	<.001	3	4
LUNG_NSCLC_LUSC	CD302 →	-1.416	-1.560	.001	<.001	3	4
SKIN	ACP2 →	-0.549	-1.068	.002	.004	3	4
STOMACH	BORCS5 →	+0.865	+1.309	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KANSL3 by Renal water absorption activity — LUNG_SCLC

Explore this box plot interactively →