Renal water absorption

Across TCGA cell cohorts, RNA activity of the Renal water absorption pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HYAL2, AVPR2, and LRRFIP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal water absorption activity versus HYAL2 in LUNG_SCLC (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HYAL2 →	+1.052	+0.723	<.001	<.001	3	10
OVARY	AVPR2 →	-1.169	-0.269	<.001	<.001	3	9
LUNG_NSCLC_LUSC	LRRFIP1 →	-0.932	-0.272	<.001	<.001	3	7
SOFT_TISSUE	CCDC186 →	-0.478	-0.206	.001	<.001	3	7
LUNG_NSCLC_LUSC	TECPR1 →	-1.358	-0.244	.001	.003	3	7
LUNG_NSCLC_LUSC	GCC2 →	-0.666	-0.208	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070295 vs HYAL2 — LUNG_SCLC

Explore this scatter interactively →