Renal sodium ion absorption

Across TCGA patient cohorts, RNA activity of the Renal sodium ion absorption pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DMAC1P1, RN7SKP275, and DUSP16, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal sodium ion absorption activity versus DMAC1P1 in LUAD (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DMAC1P1 →	-0.599	-0.488	<.001	<.001	3	3
BRCA	RN7SKP275 →	+0.523	+0.226	.009	.003	3	3
COAD	DUSP16 →	+0.429	+0.345	.002	.006	3	3
COAD	USP30 →	+0.469	+0.390	<.001	.008	3	3
BRCA	GLOD5 →	+0.610	+0.323	<.001	.001	3	3
UCEC	MIR370 →	+1.134	+0.282	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070294 vs DMAC1P1 — LUAD

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