Renal sodium ion absorption

Across TCGA cell cohorts, RNA activity of the Renal sodium ion absorption pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCAS2, LRRC34, and SNRNP40, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCAS2 grouped by Renal sodium ion absorption-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BCAS2 →	+0.743	+1.558	<.001	<.001	3	4
URINARY_TRACT	LRRC34 →	+1.234	+1.685	.001	<.001	3	4
LIVER	SNRNP40 →	+0.734	+1.542	.005	<.001	3	4
BLOOD_Leukemia	KIF20A →	+0.735	+0.777	.004	.006	3	4
BLOOD_Leukemia	MAGOH →	+0.742	+0.896	.003	.008	3	4
BLOOD_Leukemia	RBM14 →	+0.828	+1.347	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCAS2 by Renal sodium ion absorption activity — BLOOD_Leukemia

Explore this box plot interactively →