Renal sodium ion absorption

Across TCGA cell cohorts, RNA activity of the Renal sodium ion absorption pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGK1, KLHL3, and AGAP5, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal sodium ion absorption activity versus SGK1 in LUNG_NSCLC_LUSC (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SGK1 →	+3.117	+0.245	<.001	.002	3	12
OESOPHAGUS	KLHL3 →	-1.325	-0.165	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	AGAP5 →	-1.138	-0.222	.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	NDOR1 →	-0.732	-0.146	.003	.001	3	9
BONE	FAM186B →	-0.350	-0.152	.002	.002	3	8
UPPER_AERODIGESTIVE_TRACT	FCSK →	-0.905	-0.234	.002	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070294 vs SGK1 — LUNG_NSCLC_LUSC

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