Renal sodium ion absorption

Across TCGA cell cohorts, RNA activity of the Renal sodium ion absorption pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM263, MYLPF, and CMSS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal sodium ion absorption activity versus TMEM263 in LUNG_NSCLC_LUAD (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TMEM263 →	+0.724	+0.851	.001	.005	3	4
PANCREAS	MYLPF →	-0.623	-1.501	.007	<.001	3	4
PANCREAS	CMSS1 →	+0.719	+1.345	.005	.001	2	5
CNS	IMPDH2 →	+0.682	+1.168	.003	<.001	3	4
LIVER	RACGAP1 →	+0.902	+1.888	<.001	<.001	3	4
OESOPHAGUS	VAX2 →	-1.386	-1.266	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070294 vs TMEM263 — LUNG_NSCLC_LUAD

Explore this scatter interactively →