Renal sodium ion absorption

Across TCGA cell cohorts, RNA activity of the Renal sodium ion absorption pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OXSR1, MAGED2, and PFDN1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal sodium ion absorption activity versus OXSR1 in PANCREAS (Pearson r = 0.82).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OXSR1 →	+1.855	+1.878	<.001	<.001	3	13
OESOPHAGUS	MAGED2 →	+1.532	+1.883	.007	<.001	3	11
PANCREAS	PFDN1 →	+1.542	+1.725	.002	<.001	3	8
OVARY	MAP4 →	+1.579	+1.249	<.001	<.001	3	8
LIVER	PGK1 →	+1.727	+1.979	.007	<.001	3	8
CNS	DYNC1LI1 →	+0.879	+1.370	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070294 vs OXSR1 — PANCREAS

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