Renal absorption

Across TCGA patient cohorts, RNA activity of the Renal absorption pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BUB1B_S543, KIF15_S568, and CYGB, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal absorption activity versus BUB1B_S543 in LUAD (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BUB1B_S543 →	-1.004	-0.060	<.001	.002	3	9
UCEC	KIF15_S568 →	-0.634	-0.069	<.001	.002	3	9
OV	CYGB →	+0.615	+0.037	.001	.002	3	8
BRCA	PBK →	-0.785	-0.063	<.001	<.001	3	8
BRCA	CAVIN2 →	+0.751	+0.057	<.001	<.001	3	8
BRCA	COIL_T303 →	-1.102	-0.060	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070293 vs BUB1B_S543 — LUAD

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