Renal absorption

Across TCGA patient cohorts, RNA activity of the Renal absorption pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS26P54, MCCC2, and LINC02804, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal absorption activity versus RPS26P54 in CCRCC (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPS26P54 →	-0.093	-0.217	.007	.003	3	4
BRCA	MCCC2 →	+0.665	+0.192	.001	.005	3	3
LUAD	LINC02804 →	+0.329	+0.160	.002	.008	3	3
GBM	PCBP3-AS1 →	+0.291	+0.157	.001	.007	3	3
BRCA	RAB8A →	+0.402	+0.218	<.001	.002	3	3
BRCA	KITLG →	+0.793	+0.217	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070293 vs RPS26P54 — CCRCC

Explore this scatter interactively →