N-acylphosphatidylethanolamine metabolic process

Across TCGA patient cohorts, RNA activity of the N-acylphosphatidylethanolamine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLAAT3, PAK1IP1, and RECQL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-acylphosphatidylethanolamine metabolic process activity versus PLAAT3 in GBM (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLAAT3 →	+0.502	+0.068	.002	<.001	3	6
GBM	PAK1IP1 →	-0.245	-0.071	.002	.001	3	5
LUAD	RECQL →	-0.301	-0.060	<.001	.001	3	4
GBM	SCIN →	+0.742	+0.076	.005	<.001	2	5
GBM	SETD1A →	-0.188	-0.060	.005	.005	3	4
LUAD	SETD7 →	+0.326	+0.066	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070292 vs PLAAT3 — GBM

Explore this scatter interactively →