N-acylethanolamine metabolic process

Across TCGA patient cohorts, RNA activity of the N-acylethanolamine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLS1, GDPD3, and RBM47, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-acylethanolamine metabolic process activity versus PLS1 in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PLS1 →	+0.675	+0.056	<.001	<.001	3	7
PDAC	GDPD3 →	+0.932	+0.074	<.001	<.001	3	6
OV	RBM47 →	+0.392	+0.056	<.001	<.001	3	6
LSCC	C1orf226_S198 →	+0.863	+0.060	<.001	<.001	3	6
HNSC	EPN3 →	+0.715	+0.082	<.001	<.001	3	6
PDAC	MISP3_S91 →	+0.733	+0.060	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070291 vs PLS1 — OV

Explore this scatter interactively →