N-acylethanolamine metabolic process

Across TCGA cell cohorts, RNA activity of the N-acylethanolamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO45, ZNF222, and PTPN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXO45 grouped by N-acylethanolamine metabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	FBXO45 →	-1.121	-1.539	.004	.003	3	4
BLOOD_Leukemia	ZNF222 →	-1.091	-1.604	.002	<.001	3	4
BREAST	PTPN2 →	+0.850	+0.622	<.001	.004	3	3
SKIN	GAS2L1 →	-0.742	-0.602	.002	.008	2	4
OESOPHAGUS	SEMA7A →	-1.988	-1.153	<.001	.006	3	3
KIDNEY	ERGIC1 →	-1.111	-1.379	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXO45 by N-acylethanolamine metabolic process activity — KIDNEY

Explore this box plot interactively →