N-acylethanolamine metabolic process

Across TCGA cell cohorts, RNA activity of the N-acylethanolamine metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAI4, CCDC47, and RPE65, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAI4 grouped by N-acylethanolamine metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DNAI4 →	-0.106	-0.088	.004	.004	3	5
BONE	CCDC47 →	+0.262	+0.151	.003	.003	3	5
KIDNEY	RPE65 →	+0.340	+0.139	.007	.001	3	4
KIDNEY	GATA5 →	+0.259	+0.101	<.001	.002	3	4
BONE	ERBB2 →	+0.237	+0.139	<.001	<.001	3	4
OESOPHAGUS	TREX2 →	+0.255	+0.125	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAI4 by N-acylethanolamine metabolic process activity — SKIN

Explore this box plot interactively →