N-acylethanolamine metabolic process

Across TCGA cell cohorts, RNA activity of the N-acylethanolamine metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE4B, TAAR1, and DYNLT1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBE4B grouped by N-acylethanolamine metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	UBE4B →	-0.471	-1.648	.002	<.001	3	2
BREAST	TAAR1 →	+0.144	+1.648	.001	<.001	3	2
BREAST	DYNLT1 →	-0.155	-1.496	.001	.001	3	2
BREAST	NR1D2 →	+0.237	+2.281	.009	.001	3	2
BREAST	DDO →	+0.408	+2.054	.001	<.001	3	2
BREAST	CLSPN →	-0.284	-1.934	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBE4B by N-acylethanolamine metabolic process activity — BREAST

Explore this box plot interactively →