N-acylethanolamine metabolic process

Across TCGA cell cohorts, RNA activity of the N-acylethanolamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF160, DENND4A, and TMOD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-acylethanolamine metabolic process activity versus ZNF160 in LUNG_SCLC (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF160 →	+0.921	+0.326	.007	.007	3	2
LUNG_SCLC	DENND4A →	-1.048	-0.417	.009	<.001	3	2
PANCREAS	TMOD1 →	+0.640	+0.470	<.001	.004	3	2
BREAST	TPI1 →	-0.846	-1.738	<.001	<.001	3	2
BREAST	HNMT →	-2.297	-1.819	.006	<.001	3	2
BREAST	PRH1 →	-0.703	-1.738	<.001	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070291 vs ZNF160 — LUNG_SCLC

Explore this scatter interactively →