Axonemal dynein complex assembly

Across TCGA patient cohorts, RNA activity of the Axonemal dynein complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DPCD, WDR54, and BBS2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axonemal dynein complex assembly activity versus DPCD in UCEC (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DPCD →	+0.606	+0.167	<.001	<.001	3	8
UCEC	WDR54 →	+0.554	+0.220	<.001	<.001	3	7
UCEC	BBS2 →	+0.474	+0.190	<.001	<.001	3	7
UCEC	BBS7 →	+0.329	+0.160	<.001	<.001	3	7
BRCA	TTC21B →	+0.304	+0.053	<.001	<.001	3	7
BRCA	WDR19 →	+0.491	+0.079	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070286 vs DPCD — UCEC

Explore this scatter interactively →