Axonemal dynein complex assembly

Across TCGA patient cohorts, RNA activity of the Axonemal dynein complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPAG1, DLC1, and CHST11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axonemal dynein complex assembly activity versus SPAG1 in COAD (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SPAG1 →	+0.858	+0.303	<.001	<.001	3	5
LUAD	DLC1 →	-0.512	-0.544	.004	.007	3	4
COAD	CHST11 →	-0.607	-0.255	.004	.001	3	4
COAD	CDH17 →	+0.676	+0.271	<.001	<.001	3	4
CCRCC	CENPS →	+0.217	+0.540	.006	.005	3	4
CCRCC	C1S →	-1.068	-0.678	<.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070286 vs SPAG1 — COAD

Explore this scatter interactively →