Axonemal dynein complex assembly

Across TCGA cell cohorts, RNA activity of the Axonemal dynein complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH3BP1, PIANP, and THYN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SH3BP1 grouped by Axonemal dynein complex assembly-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SH3BP1 →	+0.621	+0.884	.005	.002	3	4
LUNG_SCLC	PIANP →	+3.047	+1.260	<.001	.002	3	4
SOFT_TISSUE	THYN1 →	+0.929	+1.451	<.001	<.001	3	4
LUNG_SCLC	UBE2Z →	-0.501	-1.236	<.001	<.001	3	4
LUNG_NSCLC_LUAD	TPX2 →	+0.773	+1.000	<.001	<.001	3	4
BREAST	THEMIS2 →	+1.061	+0.674	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SH3BP1 by Axonemal dynein complex assembly activity — SKIN

Explore this box plot interactively →