Axonemal dynein complex assembly

Across TCGA cell cohorts, RNA activity of the Axonemal dynein complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HIPK3, LGALS8, and SCAF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axonemal dynein complex assembly activity versus HIPK3 in STOMACH (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HIPK3 →	+0.876	+0.242	.003	.003	3	4
BLOOD_Lymphoma	LGALS8 →	+2.290	+1.158	.003	.002	2	4
BLOOD_Myeloma	SCAF1 →	+1.099	+1.948	.002	.004	3	3
BLOOD_Lymphoma	NF2 →	+0.609	+1.010	.001	.003	3	3
LIVER	PDS5A →	+1.054	+1.775	.003	.002	2	4
OESOPHAGUS	PDZD9 →	+0.127	+1.434	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070286 vs HIPK3 — STOMACH

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