Pyroptosis

Across TCGA patient cohorts, RNA activity of the Pyroptosis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, SAMHD1, and SAMSN1_S23, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyroptosis activity versus RCSD1 in GBM (Pearson r = 0.82).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCSD1 →	+0.619	+0.081	<.001	<.001	3	10
GBM	SAMHD1 →	+0.472	+0.069	<.001	<.001	3	10
OV	SAMSN1_S23 →	+0.722	+0.071	.001	<.001	3	10
GBM	SASH3 →	+0.545	+0.077	<.001	<.001	3	10
GBM	SEPTIN1 →	+1.313	+0.080	<.001	.001	3	10
BRCA	SERPINB9 →	+0.506	+0.051	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070269 vs RCSD1 — GBM

Explore this scatter interactively →