Pyroptosis

Across TCGA patient cohorts, RNA activity of the Pyroptosis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD72, FYB1, and TLR8, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyroptosis activity versus CD72 in LSCC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CD72 →	+0.699	+0.173	<.001	<.001	3	8
LSCC	FYB1 →	+1.055	+0.186	<.001	<.001	3	8
UCEC	TLR8 →	+0.747	+0.167	.004	.002	3	8
GBM	NFAM1 →	+0.680	+0.237	<.001	<.001	3	8
LSCC	SCIMP →	+0.616	+0.171	<.001	<.001	3	8
GBM	CCR5 →	+0.743	+0.159	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070269 vs CD72 — LSCC

Explore this scatter interactively →