Pyroptosis

Across TCGA cell cohorts, RNA activity of the Pyroptosis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFAB1, ISOC1, and MDN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDUFAB1 grouped by Pyroptosis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NDUFAB1 →	+0.503	+0.862	.004	.002	3	4
LARGE_INTESTINE	ISOC1 →	+0.883	+0.728	.001	.005	3	4
LARGE_INTESTINE	MDN1 →	+0.946	+1.028	.001	.004	3	3
SOFT_TISSUE	RNF130 →	-0.582	-1.661	.002	<.001	3	3
SOFT_TISSUE	UPF2 →	-0.642	-1.415	.008	.003	3	3
SOFT_TISSUE	ACSM3 →	+0.275	+1.428	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDUFAB1 by Pyroptosis activity — LARGE_INTESTINE

Explore this box plot interactively →