Cornification

Across TCGA cell cohorts, RNA activity of the Cornification pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNPT1, RNF122, and ANO9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cornification activity versus PNPT1 in PANCREAS (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PNPT1 →	-0.899	-0.528	.003	.006	3	4
BLOOD_Lymphoma	RNF122 →	-1.482	-1.163	.006	.001	3	3
BLOOD_Lymphoma	ANO9 →	-2.531	-1.094	.001	.002	3	3
BLOOD_Lymphoma	UBE2J1 →	-1.406	-0.950	.009	.004	3	3
LARGE_INTESTINE	ENY2 →	-0.503	-0.739	.005	<.001	3	3
LUNG_SCLC	CLMN →	+1.623	+0.913	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070268 vs PNPT1 — PANCREAS

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