Necroptotic process

Across TCGA cell cohorts, RNA activity of the Necroptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMA7, RNF7, and CTSZ, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMA7 grouped by Necroptotic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TMA7 →	-0.738	-0.641	<.001	.001	3	4
BONE	RNF7 →	-1.102	-1.372	.002	.002	3	3
SOFT_TISSUE	CTSZ →	-3.950	-0.877	<.001	.005	3	3
SOFT_TISSUE	KIF18A →	-1.231	-1.245	<.001	.008	3	3
SOFT_TISSUE	ATP2C1 →	-0.645	-0.928	.003	.002	3	3
SOFT_TISSUE	ZBTB8OS →	-0.626	-1.207	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMA7 by Necroptotic process activity — BREAST

Explore this box plot interactively →