Necroptotic process

Across TCGA cell cohorts, RNA activity of the Necroptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYLD, FAS, and BIRC2, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Necroptotic process activity versus CYLD in BONE (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CYLD →	+1.582	+0.089	.004	.002	3	15
BLOOD_Lymphoma	FAS →	+2.542	+0.085	<.001	<.001	3	13
SKIN	BIRC2 →	+1.133	+0.086	<.001	<.001	3	10
BLOOD_Lymphoma	SQOR →	+2.304	+0.065	<.001	<.001	3	10
CNS	IFIT5 →	+0.870	+0.082	.002	.001	3	10
BONE	ZNF74 →	-0.905	-0.067	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070266 vs CYLD — BONE

Explore this scatter interactively →