Necroptotic process

Across TCGA cell cohorts, RNA activity of the Necroptotic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHLPP1, CENPM, and TRIM35, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Necroptotic process activity versus PHLPP1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PHLPP1 →	-0.968	-0.214	.007	.003	3	4
SKIN	CENPM →	-1.026	-0.647	<.001	.004	3	3
LUNG_SCLC	TRIM35 →	-0.583	-0.176	.004	.004	2	4
LUNG_SCLC	RAB15 →	-1.485	-0.182	.004	.004	3	3
LUNG_SCLC	RPL29 →	+0.785	+0.163	<.001	<.001	3	3
SKIN	FCMR →	-2.048	-0.586	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070266 vs PHLPP1 — UPPER_AERODIGESTIVE_TRACT

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