Regulation of mucus secretion

Across TCGA patient cohorts, RNA activity of the Regulation of mucus secretion pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKCE, SMAD2, and SPTBN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mucus secretion activity versus PRKCE in UCEC (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRKCE →	+0.372	+0.100	.003	.001	3	6
LSCC	SMAD2 →	-0.254	-0.082	.004	<.001	3	4
PDAC	SPTBN2 →	+0.276	+0.060	.005	<.001	3	4
PDAC	FAM83H_S998 →	+0.240	+0.046	.003	.007	2	5
LSCC	IFI35 →	+0.301	+0.077	<.001	<.001	3	4
LSCC	ZNF185 →	+0.673	+0.086	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070255 vs PRKCE — UCEC

Explore this scatter interactively →