Regulation of mucus secretion

Across TCGA cell cohorts, RNA activity of the Regulation of mucus secretion pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPIG, LRCH1, and TPM2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPIG grouped by Regulation of mucus secretion-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PPIG →	+0.779	+2.155	.003	<.001	3	4
LIVER	LRCH1 →	+1.080	+1.751	.004	.003	3	4
BLOOD_Lymphoma	TPM2 →	-2.386	-1.864	.006	.001	3	3
STOMACH	LPIN2 →	+1.150	+1.163	.003	.003	3	3
STOMACH	TANGO6 →	+0.773	+1.227	.002	<.001	3	3
STOMACH	RAB41 →	-0.139	-1.167	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPIG by Regulation of mucus secretion activity — URINARY_TRACT

Explore this box plot interactively →