Regulation of mucus secretion

Across TCGA cell cohorts, RNA activity of the Regulation of mucus secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEF2D, FKBP10, and COX5B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MEF2D grouped by Regulation of mucus secretion-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MEF2D →	+0.393	+1.797	<.001	<.001	3	4
BREAST	FKBP10 →	-0.225	-1.062	<.001	<.001	3	4
OESOPHAGUS	COX5B →	-0.132	-1.403	.003	<.001	3	4
BLOOD_Leukemia	SMUG1 →	-0.316	-1.969	.001	.005	3	4
BLOOD_Leukemia	MYL6 →	+0.213	+1.238	<.001	.001	3	4
BONE	GYPC →	+0.242	+0.142	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MEF2D by Regulation of mucus secretion activity — BLOOD_Leukemia

Explore this box plot interactively →