Mucus secretion

Across TCGA patient cohorts, RNA activity of the Mucus secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANO1, UBFD1, and ATG16L1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mucus secretion activity versus ANO1 in LSCC (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ANO1 →	+1.027	+0.083	<.001	<.001	3	7
COAD	UBFD1 →	-0.202	-0.040	.002	.004	3	6
OV	ATG16L1 →	+0.435	+0.043	<.001	<.001	3	5
COAD	DDX27 →	-0.294	-0.050	<.001	<.001	3	5
UCEC	MUC4 →	+0.808	+0.094	<.001	<.001	3	5
UCEC	XRCC1_S241 →	-0.416	-0.062	.007	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070254 vs ANO1 — LSCC

Explore this scatter interactively →