Mucus secretion

Across TCGA patient cohorts, RNA activity of the Mucus secretion pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAUR, C1orf54, and PLK3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mucus secretion activity versus PLAUR in GBM (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLAUR →	+1.066	+0.258	<.001	.002	3	4
GBM	C1orf54 →	+0.487	+0.189	.001	.004	3	4
GBM	PLK3 →	+0.780	+0.268	<.001	.001	3	4
CCRCC	ATP1B3-AS1 →	+0.482	+0.195	.009	.004	3	4
UCEC	CCL2 →	+0.940	+0.434	<.001	.002	3	4
PDAC	CECR2 →	-0.293	-0.215	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070254 vs PLAUR — GBM

Explore this scatter interactively →