Mucus secretion

Across TCGA cell cohorts, RNA activity of the Mucus secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCF12, PPP1R7, and TAL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TCF12 grouped by Mucus secretion-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TCF12 →	+0.253	+0.269	<.001	.004	3	4
BREAST	PPP1R7 →	-0.320	-0.375	<.001	.001	3	4
BONE	TAL1 →	+0.160	+1.312	.002	<.001	3	4
CNS	FKBP5 →	+0.220	+0.930	<.001	<.001	3	3
SOFT_TISSUE	MSL3 →	+0.242	+1.651	.006	<.001	3	3
BREAST	TCF7 →	-0.173	-0.332	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TCF12 by Mucus secretion activity — LIVER

Explore this box plot interactively →