Mucus secretion

Across TCGA cell cohorts, RNA activity of the Mucus secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCL1A, CD276, and KCTD9, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TCL1A grouped by Mucus secretion-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TCL1A →	-0.115	-0.307	.002	.007	3	2
BREAST	CD276 →	+0.241	+0.293	.001	.001	3	2
BREAST	KCTD9 →	+0.226	+0.354	.006	.004	3	2
BREAST	CITED2 →	-0.156	-0.275	<.001	<.001	3	2
BREAST	ZFYVE1 →	-0.151	-0.291	.004	.003	3	2
BREAST	ESRRA →	-0.240	-0.434	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TCL1A by Mucus secretion activity — BREAST

Explore this box plot interactively →